Rohe Hangarau Glutaraldehyde: He Huarahi Hou i roto i te Hangarau Ārai-Whakapūmau

I roto i te mara o ngā whakaurunga pūnaha ngākau, kua roa te whakamahinga o te glutaraldehyde hei rongoā i ngā kiko kararehe (pērā i te pericardium kau) hei hanga i ngā takirere bioprosthetic. Heoi, ko ngā rōpū aldehyde kore utu e toe ana mai i ngā tukanga tuku iho ka arahi ki te whakapūmautanga i muri i te whakaurunga, ka whakararu i te roa o te ora o ngā hua.

Hei whakatika i tēnei wero, i roto i tētahi rangahau hou i whakaputaina i te Paenga-whāwhā 2025, i whakauruhia he otinga hou mō te maimoatanga ārai-whakapūkara (ingoa hua: Periborn), ā, i tutuki ai he ahunga whakamua whakamiharo.

1. Ngā Whakapai Ake Hangarau Matua:

Ka whakaurua mai e tēnei otinga ētahi whakapainga matua ki te tukanga honohono glutaraldehyde tuku iho:

Te Hononga-Whakawhiti o te Whakarewa Waro:
Ka mahia te hononga-whakawhiti o te glutaraldehyde i roto i tētahi whakarewa waro i titoa mai i te 75% etanoru + 5% oktanol. Mā tēnei huarahi ka āwhina i te tango pai ake i ngā phospholipid kiko i te wā e hono-whakawhiti ana—ko ngā phospholipid ngā pae matua mō te whakapūpūtanga.

Kaihoko Whakakī-Ātea:

I muri i te hononga whakawhiti, ka whakamahia te polyethylene glycol (PEG) hei whakakī ātea, ka uru ki roto i ngā āputa i waenga i ngā muka collagen. Ka ārai tēnei i ngā wāhi whakatupu o ngā tioata hydroxyapatite, ā, ka ārai hoki i te urunga o te konupūmā me ngā phospholipid mai i te toto o te tinana.

Te Hiritanga o te Pūrua:

Hei whakamutunga, ka whakakorea e te maimoatanga ki te glycine ngā rōpū aldehyde kore utu e toe ana, e tauhohe ana, ā, ka whakakorea atu tētahi atu mea matua e whakaoho ana i te whakapūkara me te paitini pūtau.

2. Ngā Hua Hauora Tino Pai:

Kua whakamahia tēnei hangarau ki tētahi tūāpapa pericardial kau e huaina nei ko "Periborn." I whakaatuhia e tētahi rangahau whai muri haumanu i hipokina ai te 352 tūroro mō ngā tau 9 kua hipa he kore mahi anō nā ngā take e pā ana ki te hua tae atu ki te 95.4%, e whakaū ana i te whai huatanga o tēnei rautaki hou mō te ārai i te whakapūkara me tōna roanga roa.

Te Hiranga o tēnei Huarahi Whakamua:

Ehara i te mea ka aro noa ki tētahi wero roa i roto i te mara o ngā takirere bioprosthetic, ka whakaroa ake i te roa o te ora o te hua, engari ka werohia hoki he kaha hou ki te whakamahinga o te glutaraldehyde i roto i ngā rauemi hauora kounga teitei.